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Nitroglycerin forms free radical nitric oxide (NO) whichactivates guanylate cyclase, NITROGLYCERIN GENERIC NAME resulting in an increase of guanosine3'5' monophosphate (cyclic GMP) in smooth muscle and othertissues. These events lead to dephosphorylation of myosin lightchains, which regulate the contractile state in smooth muscle, andresult in vasodilation. When using the sublingual tablets - those placed under thetongue - you should feel a burning or tingling nitroglycerin bottle. This indicates thedrug is effective nitroglycerin (nitrostat) 0.4 mg sublingual tablet. You should replace these tablets every sixmonths to ensure they are effective where to buy nitroglycerine.
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